Histo-pathological Study of 100 Cases of Prostatic Nodules

Objective: This study is planned to evaluate the histological lesions of prostatic specimens and it’s correlation with the clinical data.Materials and Methods: The present study is a prospective study, undertaken in the Department of Pathology, Mahatma Gandhi Medical College, Jaipur, Rajasthan, during the period of July 2010 to May 2012. This study was conducted on 100 prostatic specimens referred to department of pathology. Brief clinical data were noted from the case records, which included the age, presenting symptoms, DRE findings, serum PSA levels and clinical diagnosis. All the prostatic specimens were subjected to H&E, AgNOR staining method. Results: Out of 100 cases studied, commonest pathology encountered was benign lesion constituting 92% and malignant lesions were 08%.Out of 92 cases of benign lesions, 70 cases (63.64%) were diagnosed as nodular hyperplasia without prostatitis, 20 cases(17.69%) were diagnosed as nodular hyperplasia with prostatitis & graulomatous prostatitis and squamous metaplasia in 01 case and clear cell hyperplasia in 01 case. Clinical diagnosis of prostatic carcinoma was made in 08 cases which correlated histologically. Gleason’s score of 7 was seen in 75% of the cases and 6 was seen in 25% cases. Mean AgNOR count in benign and malignant lesions were 1.57±0.13 and 4.8±0.2 respectively. Conclusion: Prostatic carcinoma shows heterogeneity of differentiation, nuclear anaplasia, cytoplasm, functional differentiation and DNA content. There is a need for research on all aspects of this disease. Further refinement of diagnostic techniques and the development of new therapeutic modalities for the treatment of systemic disease.